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| Common Name | Scientific Name | |
| Paleseed Plantain | Plantago virginica | |
| Palmer Amaranth | Amaranthus palmeri | |
| Palmleaf Morningglory | Ipomoea wrightii | |
| Panicum, Fall | Panicum dichotomiflorum | |
| Pansy, Wild | Viola arvensis | |
| Parsnip, Wild | Pastinaca sativa | |
| Partridgepea | Cassia fasciculata | |
| Passionflower, Maypop | Passiflora incarnata | |
| Pear, Prickly | Opuntia humifusa | |
| Pea, Sweet | Lathyrus latifolius | |
| Pennsylvania Smartweed | Polygonum pensylvanicum | |
| Pennycress, Field | Thlaspi arvense | |
| Pennycress, Perfoliate | Thlaspi perfoliatum | |
| Pennycress, Thoroughwort | Thlaspi perfoliatum | |
| Pennywort, Marsh | Hydrocotyle umbellata | |
| Pepperweed, Field | Lepidium campestre | |
| Pepperweed, Virginia | Lepidium virginicum | |
| Perennial Lupine | Lupinus perennis | |
| Perfoliate Pennycress | Thlaspi perfoliatum | |
| Perilla Mint | Perilla frutescens | |
| Persian Speedwell | Veronica persica | |
| Phlox, Creeping | Phlox subulata | |
| Phyllanthus, Long-stalked | Phyllanthus tenellus | |
| Pickerelweed | Pontederia cordata | |
| Pigweed, Prostrate | Amaranthus blitoides | |
| Pigweed, Redroot | Amaranthus retroflexus | |
| Pigweed, Smooth | Amaranthus hybridus | |
| Pigweed, Spiny | Amaranthus spinosus | |
| Pineapple-weed | Matricaria matricarioides | |
| Pitted Morningglory | Ipomoea lacunosa | |
| Plantain, American Water | Alisma subcordatum | |
| Plantain, Blackseed | Plantago rugelii | |
| Plantain, Broadleaf | Plantago major | |
| Plantain, Buckhorn | Plantago lanceolata | |
| Plantain, Paleseed | Plantago virginica | |
| Plumeless Thistle | Carduus acanthoides | |
| Poinsettia, Wild | Euphorbia dentata | |
| Poison Hemlock | Conium maculatum | |
| Poison Ivy | Toxicodendron radicans | |
| Pokeweed, Common | Phytolacca americana | |
| Pondweed, Curlyleaf | Potamogeton crispus | |
| Pondweed, Slender | Potamogeton pusillus | |
| Pondweed, Variable-leaf | Potamogeton diversifolius | |
| Poorjoe | Diodia teres | |
| Poppy, Field | Papaver dubium | |
| Potato Vine | Dioscorea batatas | |
| Prickly Lettuce | Lactuca serriola | |
| Prickly Pear | Opuntia humifusa | |
| Prickly Sida | Sida spinosa | |
| Primrose, Creeping | Ludwigia palustris | |
| Prostrate Knotweed | Polygonum aviculare | |
| Prostrate Amaranth | Amaranthus blitoides | |
| Prostrate Pigweed | Amaranthus blitoides | |
| Puncturevine | Tribulus terrestris | |
| Purple Deadnettle | Lamium purpureum | |
| Purple Cudweed | Gnaphalium purpureum | |
| Purple Loosestrife | Lythrum salicaria | |
| Purple Lovegrass | Eragrostis spectabilis | |
| Purple Nutsedge | Cyperus rotundus | |
| Purpletop | Tridens flavus | |
| Purslane, Common | Portulaca oleracea |
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