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| Common Name | Scientific Name | |
| Ladysthumb | Polygonum persicaria | |
| Lambsquarters, Common | Chenopodium album | |
| Large Crabgrass | Digitaria sanguinalis | |
| Lawn Burweed | Soliva pterosperma | |
| Leaf-cup, Yellow-flowered | Smallanthus uvedalia | |
| Lespedeza, Common | Lespedeza striata | |
| Lespedeza, Sericea | Lespedeza cuneata | |
| Lettuce, Prickly | Lactuca serriola | |
| Little Barley | Hordeum pusillum | |
| Lizard's Tail | Saururus cernuus | |
| Locust, Black | Robinia pseudoacacia | |
| Long-beaked Arrowhead | Sagittaria australis | |
| Long Smooth-fruited Poppy | Papaver dubium | |
| Longspine Sandbur | Cenchrus longispinus | |
| Long-stalked Phyllanthus | Phyllanthus tenellus | |
| Loosestrife, Purple | Lythrum salicaria | |
| Lovegrass, Purple | Eragrostis spectabilis | |
| Lupine, Perennial | Lupinus perennis |
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