Cynthia Denbow

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Research scientist

111 Price Hall (0331)
Virginia Tech
Blacksburg, VA 24061

Phone: (540) 231-6155
Fax: (540) 231-7477
E-Mail: cdenbow at vt.edu

Education| Research Interests| Teaching| Grants| Experience| Professional Activities| Memberships| Selected Publications

Education

  • Ph.D., Dept. of Plant Pathology, Physiology, and Weed Science, Virginia Tech, 1997
  • M.S., Dept. of Poultry Science, North Carolina State University, Raleigh, 1980
  • B.S., Dept. of Biology and Poultry Science, North Carolina State University, Raleigh, 1977

Research Interests

My major research focus involves studying the feasibility of using medicinal plants as alternative sources of antibiotics in poultry feed for growth promotion and disease prevention. There has long been an interest in screening plants and their derived natural products for biological activity, often with the aim of producing new drugs. A growing body of evidence suggests that medicinal plants are good candidates for developing new agents for the treatment and prevention of bacterial infections. Widespread use of antimicrobials for disease control and growth promotion in animals such as poultry has been paralleled by an increase in resistance in those bacteria such as Salmonella and Campylobacter that can spread from animals, often through food, to cause infections in humans. The indiscriminate use of antibiotics could ultimately compromise the treatment of bacterial infections in humans as many of these drugs are identical to or closely resemble drugs used in human medicine. My research may provide Virginia agriculture with potential new sources of plant-derived antibiotics as growth promoters thus decreasing reliance on standard antibiotics and risking increases in bacterial resistance spreading from animals to the environment and more importantly into the food production chain.

Teaching

  • PPWS 3505 Plant Physiology and the Environment
  • PPWS 3506 Plant Physiology and the Environment
  • PPWS 3514 Plant Physiology Laboratory
  • ENT/PPWS 5624 Animal and Plant Biosafety and Biosecurity

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Grants

  • Screening of Medicinal Plants as Potential Substitutes for Dietary Antibiotics in Poultry, Virginia Agricultural Council, C. Denbow and D.M. Denbow, Co-investigators, $21,000, July 1, 2006-June 30, 2007

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Experience

  • Research Scientist (hard-funded research faculty), Dept. of Plant Pathology, Physiology, and Weed Science, Virgina Tech, 1997-present
  • Ph.D graduate student (part-time, while working full-time), Dept. of Plant Pathology, Physiology, and Weed Science, Virgina Tech, 1988-1997
  • Laboratory Specialist Senior, Dept. of Plant Pathology, Physiology, and Weed Science, Virgina Tech, 1986-1997
  • Laboratory Specialist A, Dept. of Dairy Science, Virgina Tech, 1984-1986
  • Laboratory Specialist A, Dept. of Biology, Virgina Tech,, 1981-1984
  • Laboratory Technician A, Dept. of Agronomy, Virgina Tech,, 1980-1981

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Professional Activities and Service

  • Faculty advisor for Alpha Zeta Fraternity

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Memberships

  • Sigma Xi
  • American Society of Plant Biologists

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Selected Publications

  • Denbow, C.J., S. Lang, and C.L. Cramer, 1996. The N-terminal domain of tomato 3-hydroxy-3-methylglutaryl-CoA reductases: sequence, microsomal targeting, and glycosylation. J. Biol. Chem. 271:9710-9715
  • Weissenborn, D.L., C.J. Denbow, M. Laine, S.S. Lang, Z. Yang, X. Yu, and C.L. Cramer, 1995. HMG-Co A reductase and terpenoid phytoalexins: molecular specialization within a complex pathway. Physiol. Plant. 93:393-400
  • Cramer, C.L., D. Weissenborn, C.K. Cottingham, C.J. Denbow, J.D. Eisenback, D.N. Radin, and X. Yu, 1993. Regulation of defense-related gene expression during plant-pathogen interaction. J. Nematology 25:507-518
  • Park, H., C.J. Denbow, and C.L. Cramer, 1992. Structure and nucleotide sequence of tomato HMG2 encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. Plant Mol. Bio. 20:327-331
  • Denbow, C.J., K.S. Perera, F.C. Gwazdauskas, R.M. Akers, R.E. Pearson, and M.L. McGilliard, 1986. Effect of season and stage of lactation on plasma glucose and insulin following glucose injection in Holstein cattle. J. Dairy Sci. 69:211-216
  • Denbow, C.J., J.M. Conroy, and K.D. Elgert, 1984. Macrophage-derived prostaglandin E2 modulation of the mixed lymphocyte reaction: an anomaly of increased production and decreased T cell susceptibility during tumor growth. Cellular Immunol. 84:1-13
  • Jones, C.A., F.W. Edens, and D.M. Denbow, 1981. Rectal temperature and blood chemical responses of young chickens given E. coli endotoxin. Poultry Sci. 60:2189-2194
  • Jones, C.A., F.W. Edens, and D.M. Denbow, 1982. Peripherally administered cations do not modify febrile responses induced in chickens by Escherichia coli. Poultry Sci. 61:1322-1328
  • Jones, C.A., F.W. Edens, and D.M. Denbow, 1983. Influence of age on the temperature response of chickens to E. coli and S. typhimurium endotoxins. Poultry Sci. 62:1553-1558

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